Reactome | Regulation of APC/C activators between G1/S and early anaphase

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Regulation of APC/C activators between G1/S and early anaphase Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911142
displayName	Regulation of APC/C activators between G1/S and early anaphase
eventOf	[Pathway:R-DME-174143] APC/C-mediated degradation of cell cycle proteins - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8978681] regulation of anaphase-promoting complex-dependent catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-188371] Association of Cyclin A:Cdk2 with Cdh1 - Drosophila melanogaster [Reaction:R-DME-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Drosophila melanogaster [Reaction:R-DME-174139] Dissociation of phospho-Cdh1 from the APC/C complex - Drosophila melanogaster [Reaction:R-DME-174097] Association of Emi1 with Cdh1 - Drosophila melanogaster [Reaction:R-DME-174235] Association of Emi1 with Cdc20 - Drosophila melanogaster [Pathway:R-DME-176417] Phosphorylation of Emi1 - Drosophila melanogaster [Pathway:R-DME-174113] SCF-beta-TrCP mediated degradation of Emi1 - Drosophila melanogaster [Reaction:R-DME-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Drosophila melanogaster [Pathway:R-DME-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-176408] Regulation of APC/C activators between G1/S and early anaphase - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Regulation of APC/C activators between G1/S and early anaphase
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-176408
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-174143] APC/C-mediated degradation of cell cycle proteins
(inferredTo)	[Pathway:R-HSA-176408] Regulation of APC/C activators between G1/S and early anaphase

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