Reactome | TGFBR2 recruits TGFBR1

Schema > Reaction > Entries

TGFBR2 recruits TGFBR1 Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10839984
displayName	TGFBR2 recruits TGFBR1
eventOf	[Pathway:R-DME-2173789] TGF-beta receptor signaling activates SMADs - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-170843] TGFBR2 phosphorylates TGFBR1 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-170846] TGFBR2 recruits TGFBR1 - Homo sapiens
input	[Complex:R-DME-170865] Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] 2 × [Complex:R-DME-2187279] TGFBR1:FKBP1A [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TGFBR2 recruits TGFBR1 Type II receptor recruits type I receptor
output	2 × [EntityWithAccessionedSequence:R-DME-2026007] Fkbp12 [cytosol] [Complex:R-DME-170840] TGFB1:TGFBR2:TGFBR1 [plasma membrane]
precedingEvent	[Reaction:R-DME-170861] Dimeric TGF-beta-1 binds to the receptor - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-170846
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2173789] TGF-beta receptor signaling activates SMADs
(precedingEvent)	[Reaction:R-DME-170843] TGFBR2 phosphorylates TGFBR1
(inferredTo)	[Reaction:R-HSA-170846] TGFBR2 recruits TGFBR1

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