Reactome | Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B

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Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B Show undefined attributes

catalystActivity	[CatalystActivity:10839835] phosphoprotein phosphatase activity of CDC25B [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10839837
displayName	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B
eventOf	[Pathway:R-DME-69273] Cyclin A/B1/B2 associated events during G2/M transition - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-2990882] CDK1 phosphorylates NUP98 - Drosophila melanogaster [Reaction:R-DME-4086410] CCNB:CDK1 phosphorylates BORA - Drosophila melanogaster [Reaction:R-DME-170126] Phosphorylation of Cyclin B1 in the CRS domain - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B - Homo sapiens
input	[DefinedSet:R-DME-8981821] CCNB1,CCNB2:p-T14,Y15,T161-CDK1 [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B
output	[DefinedSet:R-DME-2311324] CCNB1,CCNB2:p-T161-CDK1 [cytosol] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-DME-162657] Inactivation of Myt1 kinase - Drosophila melanogaster [Reaction:R-DME-170120] Translocation of Cdc25B to the cytoplasm - Drosophila melanogaster [Reaction:R-DME-170072] Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-170161
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DME-2990882] CDK1 phosphorylates NUP98 [Reaction:R-DME-170126] Phosphorylation of Cyclin B1 in the CRS domain [Reaction:R-DME-4086410] CCNB:CDK1 phosphorylates BORA
(hasEvent)	[Pathway:R-DME-69273] Cyclin A/B1/B2 associated events during G2/M transition
(inferredTo)	[Reaction:R-HSA-170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B

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