Reactome | Activation of MMP9 intermediate form by MMPs

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Activation of MMP9 intermediate form by MMPs Show undefined attributes

catalystActivity	[CatalystActivity:10863211] serine-type endopeptidase activity of MMP1 (2, 3, 7, 10, 13) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10863429
displayName	Activation of MMP9 intermediate form by MMPs
eventOf	[Pathway:R-DME-1592389] Activation of Matrix Metalloproteinases - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1604690] Activation of MMP9 intermediate form by MMPs - Homo sapiens
input	[DefinedSet:R-DME-1604726-3] Homologues of MMP9(60-707) [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of MMP9 intermediate form by MMPs
output	[DefinedSet:R-DME-668812-3] Homologues of MMP9(107-707) [extracellular region] [DefinedSet:R-DME-1604699-3] Homologues of MMP9(60-106) [extracellular region]
precedingEvent	[Reaction:R-DME-1592436] Initial activation of proMMP9 by MMPs - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1604690
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1592389] Activation of Matrix Metalloproteinases
(inferredTo)	[Reaction:R-HSA-1604690] Activation of MMP9 intermediate form by MMPs

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