Reactome | Activation of proMMP11 by FURIN

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10839976] serine-type endopeptidase activity of FURIN [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10863386
displayName	Activation of proMMP11 by FURIN
eventOf	[Pathway:R-DME-1592389] Activation of Matrix Metalloproteinases - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1602484] Activation of proMMP11 by FURIN - Homo sapiens
input	[DefinedSet:R-DME-1604736-3] Homologues of MMP11(32-488) [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of proMMP11 by FURIN
output	[DefinedSet:R-DME-1442477-3] Homologues of MMP11 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1602484
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-1592389] Activation of Matrix Metalloproteinases
(inferredTo)	[Reaction:R-HSA-1602484] Activation of proMMP11 by FURIN

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