Reactome | Synthesis of PA

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Synthesis of PA Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910860
displayName	Synthesis of PA
eventOf	[Pathway:R-DME-1483206] Glycerophospholipid biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20462] phosphatidic acid biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-188467] Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) - Drosophila melanogaster [Reaction:R-DME-75889] DHAP is converted to G3P by GPD1/GPD1L - Drosophila melanogaster [Reaction:R-DME-1483002] DHAP is converted to 1-acyl GO3P by GNPAT - Drosophila melanogaster [Reaction:R-DME-549112] G3P is acylated to 1-acyl LPA by AGPAT6 - Drosophila melanogaster [Reaction:R-DME-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Drosophila melanogaster [Reaction:R-DME-1482695] G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) - Drosophila melanogaster [Reaction:R-DME-6792445] LIPH, I hydrolyse PA to 2-acyl LPA - Drosophila melanogaster [Reaction:R-DME-8954398] PLD6 dimer hydrolyses cardiolipin to PA and PG - Drosophila melanogaster [Reaction:R-DME-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Drosophila melanogaster [Reaction:R-DME-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Drosophila melanogaster [Reaction:R-DME-8878787] ALPI dimer hydrolyses phosphate monoesters - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-1483166] Synthesis of PA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of PA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1483166
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1483206] Glycerophospholipid biosynthesis
(inferredTo)	[Pathway:R-HSA-1483166] Synthesis of PA

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