Reactome | PA is converted to CDP-DAG by CDS1

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PA is converted to CDP-DAG by CDS1 Show undefined attributes

catalystActivity	[CatalystActivity:10862747] phosphatidate cytidylyltransferase activity of CDS1:Mg2+ [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10862749
displayName	PA is converted to CDP-DAG by CDS1
eventOf	[Pathway:R-DME-1483226] Synthesis of PI - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-1482976] CDP-DAG is converted to PI by CDIPT - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1483121] PA is converted to CDP-DAG by CDS1 - Homo sapiens
input	[SimpleEntity:R-ALL-110614] CTP [cytosol] [SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PA is converted to CDP-DAG by CDS1
output	[SimpleEntity:R-ALL-426955] CDP-DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-DME-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Drosophila melanogaster [Reaction:R-DME-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1483121
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1483226] Synthesis of PI
(precedingEvent)	[Reaction:R-DME-1482976] CDP-DAG is converted to PI by CDIPT
(inferredTo)	[Reaction:R-HSA-1483121] PA is converted to CDP-DAG by CDS1