Reactome | Intraphagosomal pH is lowered to 5 by V-ATPase

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Intraphagosomal pH is lowered to 5 by V-ATPase Show undefined attributes

catalystActivity	[CatalystActivity:10860812] proton transmembrane transporter activity of V-ATPase [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol [Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10860814
displayName	Intraphagosomal pH is lowered to 5 by V-ATPase
eventOf	[Pathway:R-DME-1222556] ROS and RNS production in phagocytes - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1042965] phagosome acidification
inferredFrom	[Reaction:R-HSA-1222516] Intraphagosomal pH is lowered to 5 by V-ATPase - Homo sapiens
input	3 × [SimpleEntity:R-ALL-70106] H+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Intraphagosomal pH is lowered to 5 by V-ATPase
output	3 × [SimpleEntity:R-ALL-1470067] H+ [phagocytic vesicle lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1222516
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1222556] ROS and RNS production in phagocytes
(inferredTo)	[Reaction:R-HSA-1222516] Intraphagosomal pH is lowered to 5 by V-ATPase

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