Reactome | MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2

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MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 Show undefined attributes

catalystActivity	[CatalystActivity:10835944] protein serine/threonine kinase activity of MAPK3,(MAPK1) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10835950
displayName	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
eventOf	[Pathway:R-DME-74749] Signal attenuation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5686315] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DME-5686316] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
precedingEvent	[Reaction:R-DME-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-109823
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-74749] Signal attenuation
(precedingEvent)	[Reaction:R-DME-5686315] GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates
(inferredTo)	[Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2

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