Reactome | PI3K Cascade

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910932
displayName	PI3K Cascade
eventOf	[Pathway:R-DME-112399] IRS-mediated signalling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Drosophila melanogaster [Pathway:R-DME-165158] Activation of AKT2 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-109704] PI3K Cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	PI3K Cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-109704
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-112399] IRS-mediated signalling
(inferredTo)	[Pathway:R-HSA-109704] PI3K Cascade