Reactome | NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol

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NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol Show undefined attributes

catalystActivity	[CatalystActivity:11005626] 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11048453
displayName	NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol
eventOf	[Pathway:R-DDI-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9945822] NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol - Homo sapiens
input	[SimpleEntity:R-ALL-9945820] 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH
output	[SimpleEntity:R-ALL-9945802] 4a-me-5a-cholest-8-en-3-one [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9945822
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
(inferredTo)	[Reaction:R-HSA-9945822] NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol

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