Reactome | ROS,RNS oxidize ACO2:4Fe-4S

Schema > Reaction > Entries

ROS,RNS oxidize ACO2:4Fe-4S Show undefined attributes

catalystActivity	[CatalystActivity:11047555] molecular sensor activity of ACO2:4Fe-4S [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11047557
displayName	ROS,RNS oxidize ACO2:4Fe-4S
eventOf	[Pathway:R-DDI-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-9854405] Frataxin transfers Fe2+ to ACO2 - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-9854368] ROS,RNS oxidize ACO2:4Fe-4S - Homo sapiens
input	[Complex:R-DDI-9854344] ACO2:4Fe-4S [mitochondrial matrix] [DefinedSet:R-ALL-9854374] ROS,RNS [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ROS,RNS oxidize ACO2:4Fe-4S
output	[Complex:R-DDI-9854373] ACO2:3Fe-4S [mitochondrial matrix] [SimpleEntity:R-ALL-113531] Fe2+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9854368
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(precedingEvent)	[Reaction:R-DDI-9854405] Frataxin transfers Fe2+ to ACO2
(inferredTo)	[Reaction:R-HSA-9854368] ROS,RNS oxidize ACO2:4Fe-4S