Reactome | p-PKR dimer localizes to the nucleus

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11047159
displayName	p-PKR dimer localizes to the nucleus
eventOf	[Pathway:R-DDI-9833482] PKR-mediated signaling - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-9836617] p-PKR dimer phosphorylates SPHK1 - Dictyostelium discoideum
inferredFrom	[BlackBoxEvent:R-HSA-9833635] p-PKR dimer localizes to the nucleus - Homo sapiens
input	[Complex:R-DDI-9833821] p-EIF2AK2 dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-PKR dimer localizes to the nucleus
output	[Complex:R-DDI-9836331] p-EIF2AK2 dimer [nucleoplasm]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9833635
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-9833482] PKR-mediated signaling
(precedingEvent)	[Reaction:R-DDI-9836617] p-PKR dimer phosphorylates SPHK1
(inferredTo)	[BlackBoxEvent:R-HSA-9833635] p-PKR dimer localizes to the nucleus

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