Reactome | CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA

Schema > Reaction > Entries

CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA Show undefined attributes

catalystActivity	[CatalystActivity:11043235] monooxygenase activity of CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11046053
displayName	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA
eventOf	[Pathway:R-DDI-9749641] Aspirin ADME - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA - Homo sapiens
input	[SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-9749790] ST (hepatocyte) [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA
output	[SimpleEntity:R-ALL-9750014] 2,5-DHBA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-DDI-9749792] CES1,CES2 hydrolyze ASA- to ST - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9750016
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-9749641] Aspirin ADME
(inferredTo)	[Reaction:R-HSA-9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA

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