Reactome | IMPDH tetramers dehydrogenate 6TIMP to 6TXMP

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IMPDH tetramers dehydrogenate 6TIMP to 6TXMP Show undefined attributes

catalystActivity	[CatalystActivity:11000276] IMP dehydrogenase activity of IMPDH tetramers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11046002
displayName	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP
eventOf	[Pathway:R-DDI-9748787] Azathioprine ADME - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-9748957] GMPS dimer transforms 6TXMP to 6TGMP - Dictyostelium discoideum [Reaction:R-DDI-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region - Dictyostelium discoideum
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
inferredFrom	[Reaction:R-HSA-9748945] IMPDH tetramers dehydrogenate 6TIMP to 6TXMP - Homo sapiens
input	[SimpleEntity:R-ALL-9748992] 6TIMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP 6TIMP--IMPDH-->6TXMP
output	[SimpleEntity:R-ALL-9748959] 6TXMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-DDI-9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9748945
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-9748787] Azathioprine ADME
(precedingEvent)	[Reaction:R-DDI-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region [Reaction:R-DDI-9748957] GMPS dimer transforms 6TXMP to 6TGMP
(inferredTo)	[Reaction:R-HSA-9748945] IMPDH tetramers dehydrogenate 6TIMP to 6TXMP

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