Reactome | CYP3A4, CYP2B6 bind ritonavir

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11045369
displayName	CYP3A4, CYP2B6 bind ritonavir
eventOf	[Pathway:R-DDI-211945] Phase I - Functionalization of compounds - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9680865] CYP3A4, CYP2B6 bind ritonavir - Homo sapiens
input	[DefinedSet:R-DDI-211010-7] Homologues of CYP2B6 [endoplasmic reticulum membrane] [ChemicalDrug:R-ALL-9679091] ritonavir [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP3A4, CYP2B6 bind ritonavir
output	[Complex:R-DDI-9680864] CYP3A4,CYP2B6:ritinovir [endoplasmic reticulum membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9680865
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-211945] Phase I - Functionalization of compounds
(inferredTo)	[Reaction:R-HSA-9680865] CYP3A4, CYP2B6 bind ritonavir