Reactome | Activated TRAF6 synthesizes unanchored polyubiquitin chains

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Activated TRAF6 synthesizes unanchored polyubiquitin chains Show undefined attributes

catalystActivity	[CatalystActivity:11014098] ubiquitin-protein transferase activity of p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane]
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11014100
displayName	Activated TRAF6 synthesizes unanchored polyubiquitin chains
eventOf	[Pathway:R-DDI-937042] IRAK2 mediated activation of TAK1 complex - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Homo sapiens
input	[DefinedSet:R-DDI-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated TRAF6 synthesizes unanchored polyubiquitin chains
output	[Polymer:R-DDI-450152] K63polyUb [cytosol]
precedingEvent	[BlackBoxEvent:R-DDI-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Polymerisation
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-936986
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-937042] IRAK2 mediated activation of TAK1 complex
(inferredTo)	[Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains

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