Reactome | Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex

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Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11013788
displayName	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex
eventOf	[Pathway:R-DDI-975956] Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-927789] Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex - Homo sapiens
input	[Complex:R-DDI-927787] Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] [EntityWithAccessionedSequence:R-DDI-927734] UPF1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex
output	[Complex:R-DDI-927762] UPF1:eRF3 Complex on Translated mRNA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-927789
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-975956] Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
(inferredTo)	[Reaction:R-HSA-927789] Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex

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