Reactome | ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA

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ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA Show undefined attributes

catalystActivity	[CatalystActivity:11043112] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11043138
displayName	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA
eventOf	[Pathway:R-DDI-9020265] Biosynthesis of aspirin-triggered D-series resolvins - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-9020252] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-9020256] ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024479] 7(S)-Hp-17(R)-HDHA [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA
output	[SimpleEntity:R-ALL-9024602] 7S(8)-epoxy-17(R)-HDHA [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-DDI-9020251] ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9020256
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-9020265] Biosynthesis of aspirin-triggered D-series resolvins
(precedingEvent)	[Reaction:R-DDI-9020252] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2
(inferredTo)	[Reaction:R-HSA-9020256] ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA

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