Reactome | KDM6B binds iron

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11042101
displayName	KDM6B binds iron
eventOf	[Pathway:R-DDI-2559580] Oxidative Stress Induced Senescence - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-8979071] KDM6B binds iron - Homo sapiens
input	[SimpleEntity:R-ALL-111793] Fe2+ [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-1629833] trfA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	KDM6B binds iron
output	[Complex:R-DDI-3222589] KDM6B:Fe2+ [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-8979071
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-DDI-3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter
(inferredTo)	[Reaction:R-HSA-8979071] KDM6B binds iron