Reactome | UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

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UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin Show undefined attributes

catalystActivity	[CatalystActivity:11037697] cysteine-type deubiquitinase activity of UCHL3,USP7,USP9X [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11037717
displayName	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin
eventOf	[Pathway:R-DDI-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-8852134] UBA1 adenylates ubiquitin in the cytosol - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-8853514] UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin - Homo sapiens
input	[DefinedSet:R-DDI-8853517-8] Homologues of UBA52(1-128) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin
output	[DefinedSet:R-DDI-72476-8] Homologues of RPL40 [cytosol] [DefinedSet:R-DDI-939205-8] Homologues of RPS27A(1-76) [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-8853514
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes
(precedingEvent)	[Reaction:R-DDI-8852134] UBA1 adenylates ubiquitin in the cytosol
(inferredTo)	[Reaction:R-HSA-8853514] UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

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