Reactome | 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+

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3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+ Show undefined attributes

catalystActivity	[CatalystActivity:10998799] kynureninase activity of KYNU dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	10998801
displayName	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+
eventOf	[Pathway:R-DDI-71240] Tryptophan catabolism - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-71218] 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-71217] 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-34351] 3HKYN [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+ 3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine
output	[SimpleEntity:R-ALL-30487] 3HAA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29432] L-Ala [cytosol]
precedingEvent	[Reaction:R-DDI-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-71217
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-71240] Tryptophan catabolism
(precedingEvent)	[Reaction:R-DDI-71218] 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
(inferredTo)	[Reaction:R-HSA-71217] 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+

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