Reactome | Sensing of DNA Double Strand Breaks

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Sensing of DNA Double Strand Breaks Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049132
displayName	Sensing of DNA Double Strand Breaks
eventOf	[Pathway:R-DDI-5693606] DNA Double Strand Break Response - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-DDI-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Dictyostelium discoideum
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-75172] Formation of RAD50:MRE11 complex - Dictyostelium discoideum [Reaction:R-DDI-5682044] KAT5 acetylates ATM at DNA DSBs - Dictyostelium discoideum [Reaction:R-DDI-5693540] MRN activates ATM - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Sensing of DNA Double Strand Breaks
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5693548
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-DDI-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(hasEvent)	[Pathway:R-DDI-5693606] DNA Double Strand Break Response
(inferredTo)	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks