Reactome | Regulation of necroptotic cell death

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Regulation of necroptotic cell death Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050878
displayName	Regulation of necroptotic cell death
eventOf	[Pathway:R-DDI-5213460] RIPK1-mediated regulated necrosis - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:422731] regulation of necroptotic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-9687625] ATP binds MLKL - Dictyostelium discoideum [Reaction:R-DDI-9687638] MLKL binds IP4, IP5 and IP6 - Dictyostelium discoideum [Reaction:R-DDI-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-5675482] Regulation of necroptotic cell death - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of necroptotic cell death
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5675482
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5213460] RIPK1-mediated regulated necrosis
(inferredTo)	[Pathway:R-HSA-5675482] Regulation of necroptotic cell death

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