Reactome | Activated MAPK phosphorylates RAF1

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Activated MAPK phosphorylates RAF1 Show undefined attributes

catalystActivity	[CatalystActivity:11026436] protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11026463
displayName	Activated MAPK phosphorylates RAF1
eventOf	[Pathway:R-DDI-5674499] Negative feedback regulation of MAPK pathway - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5675194] Activated MAPK phosphorylates RAF1 - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-DDI-5672665-4] Homologues of p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated MAPK phosphorylates RAF1
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-DDI-5675193-4] Homologues of hyperphosphorylated RAF1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5675194
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5674499] Negative feedback regulation of MAPK pathway
(inferredTo)	[Reaction:R-HSA-5675194] Activated MAPK phosphorylates RAF1

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