Reactome | Active MTORC1 phosphorylates ULK1

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Active MTORC1 phosphorylates ULK1 Show undefined attributes

catalystActivity	[CatalystActivity:11025546] protein serine/threonine kinase activity of MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11025548
displayName	Active MTORC1 phosphorylates ULK1
eventOf	[Pathway:R-DDI-1632852] Macroautophagy - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-5673768] p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex - Dictyostelium discoideum
goBiologicalProcess	[GO_BiologicalProcess:24370] regulation of macroautophagy
inferredFrom	[Reaction:R-HSA-5672010] Active MTORC1 phosphorylates ULK1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DDI-5675639] MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Active MTORC1 phosphorylates ULK1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DDI-5675701] MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane]
precedingEvent	[Reaction:R-DDI-5672817] Active MTORC1 binds the ULK1 complex - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5672010
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1632852] Macroautophagy
(precedingEvent)	[Reaction:R-DDI-5673768] p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
(inferredTo)	[Reaction:R-HSA-5672010] Active MTORC1 phosphorylates ULK1

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