Reactome | RHO GTPases Activate NADPH Oxidases

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:1222693] phagocytic vesicle membrane [Compartment:263698] phagolysosome
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050620
displayName	RHO GTPases Activate NADPH Oxidases
eventOf	[Pathway:R-DDI-195258] RHO GTPase Effectors - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-6798174] PIK3C3:PIK3R4 phosphorylates PI to PI3P - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases Activate NADPH Oxidases
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5668599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-DDI-1222556] ROS and RNS production in phagocytes
(inferredTo)	[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases

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