Reactome | Dopa is oxidized to dopaquinone by TYR

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Dopa is oxidized to dopaquinone by TYR Show undefined attributes

catalystActivity	[CatalystActivity:11025429] catechol oxidase activity of TYR:2xCu2+ [melanosome membrane]
category	transition
compartment	[Compartment:5668572] melanosome lumen
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11025439
displayName	Dopa is oxidized to dopaquinone by TYR
eventOf	[Pathway:R-DDI-5662702] Melanin biosynthesis - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5662692] Dopa is oxidized to dopaquinone by TYR - Homo sapiens
input	2 × [SimpleEntity:R-ALL-5668568] L-Dopa [melanosome lumen] [SimpleEntity:R-ALL-5668566] O2 [melanosome lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Dopa is oxidized to dopaquinone by TYR 2 L-dopa + O2 => 2 L-dopaquinone + 2 H2O
output	2 × [SimpleEntity:R-ALL-5668574] H2O [melanosome lumen] 2 × [SimpleEntity:R-ALL-5662695] L-Dopaquinone [melanosome lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5662692
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5662702] Melanin biosynthesis
(inferredTo)	[Reaction:R-HSA-5662692] Dopa is oxidized to dopaquinone by TYR

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