Reactome | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Schema > Pathway > Entries

APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050488
displayName	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
eventOf	[Pathway:R-DDI-73933] Resolution of Abasic Sites (AP sites) - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17139] base-excision repair, gap-filling
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) - Dictyostelium discoideum [Reaction:R-DDI-5649723] POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution - Dictyostelium discoideum [Reaction:R-DDI-5649734] LIG3 ligates NEIL1,NEIL2-generated single strand break - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5649702
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-73933] Resolution of Abasic Sites (AP sites)
(inferredTo)	[Pathway:R-HSA-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Cite Us!