Reactome | GPR161 promotes cAMP production in a G alpha(s)-dependent manner

Schema > Reaction > Entries

GPR161 promotes cAMP production in a G alpha(s)-dependent manner Show undefined attributes

catalystActivity	[CatalystActivity:11024458] adenylate cyclase activity of adenylate cyclases:Mg2+ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11024460
displayName	GPR161 promotes cAMP production in a G alpha(s)-dependent manner
eventOf	[Pathway:R-DDI-5610787] Hedgehog 'off' state - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-5610749] cAMP dissociates PKA, promoting GLI processing - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-5610727] GPR161 promotes cAMP production in a G alpha(s)-dependent manner - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GPR161 promotes cAMP production in a G alpha(s)-dependent manner
output	[SimpleEntity:R-ALL-30389] cAMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5610727
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5610787] Hedgehog 'off' state
(precedingEvent)	[Reaction:R-DDI-5610749] cAMP dissociates PKA, promoting GLI processing
(inferredTo)	[Reaction:R-HSA-5610727] GPR161 promotes cAMP production in a G alpha(s)-dependent manner

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