Reactome | COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)

Schema > Reaction > Entries

COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) Show undefined attributes

catalystActivity	[CatalystActivity:11023008] histone methyltransferase activity of CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11023010
displayName	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)
eventOf	[Pathway:R-DDI-3214858] RMTs methylate histone arginines - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5205861] COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-DDI-5216232] MeR4-HIST1H4, HIST1H4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-DDI-5216236] Me2sR4-HIST1H4, MeR4-HIST1H4 [nucleoplasm]
regulatedBy	[PositiveRegulation:11023011] Positive regulation by 'SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5205861
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-3214858] RMTs methylate histone arginines
(inferredTo)	[Reaction:R-HSA-5205861] COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)

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