Reactome | Depolymerization of the Nuclear Lamina

Schema > Pathway > Entries

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050436
displayName	Depolymerization of the Nuclear Lamina
eventOf	[Pathway:R-DDI-2980766] Nuclear Envelope Breakdown - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-5221130] LPIN catalyzes conversion of phosphatidic acid to diacylglycerol - Dictyostelium discoideum [Reaction:R-DDI-5223304] DAG and Ca+2 bind to PKC and tether it to membrane - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Depolymerization of the Nuclear Lamina
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-4419969
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-2980766] Nuclear Envelope Breakdown
(inferredTo)	[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina

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