Reactome | TOPORS SUMOylates SIN3A with SUMO1

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TOPORS SUMOylates SIN3A with SUMO1 Show undefined attributes

catalystActivity	[CatalystActivity:11022232] SUMO transferase activity of TOPORS [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11022234
displayName	TOPORS SUMOylates SIN3A with SUMO1
eventOf	[Pathway:R-DDI-3899300] SUMOylation of transcription cofactors - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4085994] TOPORS SUMOylates SIN3A with SUMO1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DDI-351657] SIN3A [nucleoplasm] [Complex:R-DDI-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	TOPORS SUMOylates SIN3A with SUMO1
output	[EntityWithAccessionedSequence:R-DDI-4086071] monoSUMO1-SIN3A [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-912481] ubc9 [nucleoplasm]
precedingEvent	[Reaction:R-DDI-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-4085994
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-3899300] SUMOylation of transcription cofactors
(inferredTo)	[Reaction:R-HSA-4085994] TOPORS SUMOylates SIN3A with SUMO1

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