Reactome | Dopamine clearance from the synaptic cleft

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Dopamine clearance from the synaptic cleft Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049850
displayName	Dopamine clearance from the synaptic cleft
eventOf	[Pathway:R-DDI-112311] Neurotransmitter clearance - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-DDI-379397] Enzymatic degradation of dopamine by COMT - Dictyostelium discoideum [Pathway:R-DDI-379398] Enzymatic degradation of Dopamine by monoamine oxidase - Dictyostelium discoideum [Reaction:R-DDI-9677917] MAOA inhibitors bind MAOA:FAD - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-379401] Dopamine clearance from the synaptic cleft - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Dopamine clearance from the synaptic cleft Clearance of dopamine
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-379401
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-112311] Neurotransmitter clearance
(inferredTo)	[Pathway:R-HSA-379401] Dopamine clearance from the synaptic cleft

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