Reactome | HSP70 binds to HSP40:nascent protein

Schema > Reaction > Entries

HSP70 binds to HSP40:nascent protein Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11021680
displayName	HSP70 binds to HSP40:nascent protein
eventOf	[Pathway:R-DDI-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-3371422] ATP hydrolysis by HSP70 - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-3371590] HSP70 binds to HSP40:nascent protein - Homo sapiens
input	[Complex:R-DDI-3371515] HSP40:nascent protein [cytosol] [Complex:R-DDI-5618079] HSP70:ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HSP70 binds to HSP40:nascent protein
output	[Complex:R-DDI-3371563] HSP40:HSP70:ATP:nascent protein [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-3371590
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-DDI-3371422] ATP hydrolysis by HSP70
(inferredTo)	[Reaction:R-HSA-3371590] HSP70 binds to HSP40:nascent protein

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