Reactome | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049224
displayName	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
eventOf	[Pathway:R-DDI-9006934] Signaling by Receptor Tyrosine Kinases - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:153] insulin-like growth factor receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DDI-2428924] IGF1R signaling cascade - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	8
name	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-2404192
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)	[Pathway:R-DDI-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

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