Reactome | COQ6 hydroxylates DHB

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COQ6 hydroxylates DHB Show undefined attributes

catalystActivity	[CatalystActivity:11019220] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11019229
displayName	COQ6 hydroxylates DHB
eventOf	[Pathway:R-DDI-2142789] Ubiquinol biosynthesis - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-2162193] COQ3 methylates DHDB - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-2162187] COQ6 hydroxylates DHB - Homo sapiens
input	[SimpleEntity:R-ALL-2395504] (2Fe-2S)(1+) [mitochondrial matrix] [SimpleEntity:R-ALL-2162207] DHB [mitochondrial inner membrane] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	COQ6 hydroxylates DHB DHB is hydroxylated to DHDB by COQ6
output	[SimpleEntity:R-ALL-2395501] (2Fe-2S)2+ [mitochondrial matrix] [SimpleEntity:R-ALL-2162209] DHDB [mitochondrial inner membrane] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
precedingEvent	[Reaction:R-DDI-2162192] COQ2 ligates all-E-10PrP2 to PHB - Dictyostelium discoideum
regulatedBy	[Requirement:11019230] Requirement by 'COQ8A,B:COQ6 [mitochondrial inner membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-2162187
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-2142789] Ubiquinol biosynthesis
(precedingEvent)	[Reaction:R-DDI-2162193] COQ3 methylates DHDB
(inferredTo)	[Reaction:R-HSA-2162187] COQ6 hydroxylates DHB