Reactome | CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation

Schema > Reaction > Entries

CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation Show undefined attributes

catalystActivity	[CatalystActivity:11007913] monooxygenase activity of Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11007915
displayName	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation
eventOf	[Pathway:R-DDI-211981] Xenobiotics - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-211910] CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation - Homo sapiens
input	[SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-211906] PTXL [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-211894] HPTXL [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-211910
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-211981] Xenobiotics
(inferredTo)	[Reaction:R-HSA-211910] CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation

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