Reactome | ERKs are inactivated by dual-specific phosphatases (DUSPs)

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ERKs are inactivated by dual-specific phosphatases (DUSPs) Show undefined attributes

catalystActivity	[CatalystActivity:11006905] protein tyrosine phosphatase activity of ERK-specific DUSP [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11006907
displayName	ERKs are inactivated by dual-specific phosphatases (DUSPs)
eventOf	[Pathway:R-DDI-202670] ERKs are inactivated - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-203797] ERKs are inactivated by dual-specific phosphatases (DUSPs) - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [DefinedSet:R-DDI-199878] p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ERKs are inactivated by dual-specific phosphatases (DUSPs)
output	[DefinedSet:R-DDI-199955] MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-DDI-9610166] p-T,Y MAPK dimers translocate to nucleus - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-203797
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-202670] ERKs are inactivated
(inferredTo)	[Reaction:R-HSA-203797] ERKs are inactivated by dual-specific phosphatases (DUSPs)

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