Reactome | 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+

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5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:11006402] methylenetetrahydrofolate dehydrogenase (NADP+) activity of MTHFD1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11006404
displayName	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+
eventOf	[Pathway:R-DDI-196757] Metabolism of folate and pterines - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-200739] 5,10-methylene-THFPG [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+
output	[SimpleEntity:R-ALL-200640] 5,10-methenyl-THFPG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-200644
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-DDI-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
(inferredTo)	[Reaction:R-HSA-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+

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