Reactome | I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

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I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:11018128] inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5(4) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11018130
displayName	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
eventOf	[Pathway:R-DDI-1855183] Synthesis of IP2, IP, and Ins in the cytosol - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-1855208] I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
output	[SimpleEntity:R-ALL-1629739] I(1,4)P2 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-DDI-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Dictyostelium discoideum [Reaction:R-DDI-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Dictyostelium discoideum [Reaction:R-DDI-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane - Dictyostelium discoideum [Reaction:R-DDI-1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1855174
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1855183] Synthesis of IP2, IP, and Ins in the cytosol
(precedingEvent)	[Reaction:R-DDI-1855208] I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol
(inferredTo)	[Reaction:R-HSA-1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol