Reactome | Mitochondrial Uncoupling

Schema > Pathway > Entries

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050870
displayName	Mitochondrial Uncoupling
eventOf	[Pathway:R-DDI-1428517] Aerobic respiration and respiratory electron transport - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:6808273] adaptive thermogenesis
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-9864415] AAC1 imports a proton - Dictyostelium discoideum [Pathway:R-DDI-9673163] Oleoyl-phe metabolism - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-166187] Mitochondrial Uncoupling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Mitochondrial Uncoupling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-166187
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-1428517] Aerobic respiration and respiratory electron transport
(inferredTo)	[Pathway:R-HSA-166187] Mitochondrial Uncoupling

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