Reactome | Synthesis of PIPs at the ER membrane

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Synthesis of PIPs at the ER membrane Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050236
displayName	Synthesis of PIPs at the ER membrane
eventOf	[Pathway:R-DDI-1483255] PI Metabolism - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20474] phosphatidylinositol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Dictyostelium discoideum [Reaction:R-DDI-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Dictyostelium discoideum [Reaction:R-DDI-6809764] SBF1 binds MTMR2 - Dictyostelium discoideum [Reaction:R-DDI-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Dictyostelium discoideum [Reaction:R-DDI-6809778] PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of PIPs at the ER membrane
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1483248
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1483255] PI Metabolism
(inferredTo)	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane

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