Reactome | PC is hydrolyzed to 2-acyl LPC by PLA2G4C

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PC is hydrolyzed to 2-acyl LPC by PLA2G4C Show undefined attributes

catalystActivity	[CatalystActivity:11016528] glycerophospholipid phospholipase A1 activity of PLA2G4C [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016530
displayName	PC is hydrolyzed to 2-acyl LPC by PLA2G4C
eventOf	[Pathway:R-DDI-1482788] Acyl chain remodelling of PC - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-1482629] 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C - Dictyostelium discoideum [Reaction:R-DDI-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Dictyostelium discoideum [Reaction:R-DDI-1482533] 2-acyl LPC is acylated to PC by LPCAT - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PC is hydrolyzed to 2-acyl LPC by PLA2G4C
output	[SimpleEntity:R-ALL-975614] 2-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-DDI-1483219] PC is exchanged with PI by PITPNB - Dictyostelium discoideum [Reaction:R-DDI-1482533] 2-acyl LPC is acylated to PC by LPCAT - Dictyostelium discoideum [Reaction:R-DDI-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Dictyostelium discoideum [Reaction:R-DDI-1482547] 1-acyl LPC is acylated to PC by LPCAT - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1482827
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1482788] Acyl chain remodelling of PC
(precedingEvent)	[Reaction:R-DDI-1482629] 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Reaction:R-DDI-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Reaction:R-DDI-1482533] 2-acyl LPC is acylated to PC by LPCAT
(inferredTo)	[Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C