Reactome | ABCG4 may mediate cholesterol efflux

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ABCG4 may mediate cholesterol efflux Show undefined attributes

catalystActivity	[CatalystActivity:11016209] cholesterol transfer activity of ABCG4 dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016211
displayName	ABCG4 may mediate cholesterol efflux
eventOf	[Pathway:R-DDI-1369062] ABC transporters in lipid homeostasis - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1454928] ABCG4 may mediate cholesterol efflux - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-176478] CHOL [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCG4 may mediate cholesterol efflux
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-171149] CHOL [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1454928
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1369062] ABC transporters in lipid homeostasis
(inferredTo)	[Reaction:R-HSA-1454928] ABCG4 may mediate cholesterol efflux

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