Reactome | Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex

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Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016072
displayName	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
eventOf	[Pathway:R-DDI-69231] Cyclin D associated events in G1 - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2) - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex - Homo sapiens
input	[Complex:R-DDI-187547] CUL1:SKP1:SKP2:CKS1B [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-1226084] phospho-rblA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
output	[Complex:R-DDI-1363326] p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm]
precedingEvent	[Reaction:R-DDI-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1363328
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-69231] Cyclin D associated events in G1
(precedingEvent)	[Reaction:R-DDI-1363331] Ubiquitination of p130 (RBL2) by SCF (Skp2)
(inferredTo)	[Reaction:R-HSA-1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex

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