Reactome | Displacement of NTHL1 glycosylase by APEX1 at the AP site

Schema > Reaction > Entries

Displacement of NTHL1 glycosylase by APEX1 at the AP site Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11002287
displayName	Displacement of NTHL1 glycosylase by APEX1 at the AP site
eventOf	[Pathway:R-DDI-110357] Displacement of DNA glycosylase by APEX1 - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site - Homo sapiens
input	[EntityWithAccessionedSequence:R-DDI-50119] APEX1 [nucleoplasm] [Complex:R-DDI-110193] NTHL1:AP-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Displacement of NTHL1 glycosylase by APEX1 at the AP site
output	[Complex:R-DDI-110332] APEX1:AP-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-60537] NTH1 [nucleoplasm]
precedingEvent	[Reaction:R-DDI-110224] Cleavage of thymine glycol by NTHL1 glycosylase - Dictyostelium discoideum [Reaction:R-DDI-110226] Cleavage of cytosine glycol by NTHL1 glycosylase - Dictyostelium discoideum [Reaction:R-DDI-110227] Cleavage of dihydrouracil by NTHL1 glycosylase - Dictyostelium discoideum [Reaction:R-DDI-110229] Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-110352
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DDI-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
(hasEvent)	[Pathway:R-DDI-110357] Displacement of DNA glycosylase by APEX1
(inferredTo)	[Reaction:R-HSA-110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site