Reactome | C5a binds C5a inhibitor

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328224
displayName	C5a binds C5a inhibitor
eventOf	[Pathway:R-CFA-977606] Regulation of Complement cascade - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9957405] C5a binds C5a inhibitor - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-173677] C5 [extracellular region] [ProteinDrug:R-ALL-9957478] vilobelimab [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	C5a binds C5a inhibitor
output	[Complex:R-CFA-9957443] C5a:vilobelimab [extracellular region]
precedingEvent	[Reaction:R-CFA-173680] Activation of C5 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9957405
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-977606] Regulation of Complement cascade
(inferredTo)	[Reaction:R-HSA-9957405] C5a binds C5a inhibitor

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