Reactome | Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow

Schema > BlackBoxEvent > Entries

Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10325887
displayName	Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow
eventOf	[Pathway:R-CFA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-9861469] p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-9861484] Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-CFA-201621] PTK2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-CFA-354068] phospho-PTK2 [cytosol]
regulatedBy	[PositiveRegulation:10325888] Positive regulation by 'p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane]' [PositiveRegulation:10325889] Positive regulation by 'Integrin alphaVbeta3 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-9861484
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
(precedingEvent)	[Reaction:R-CFA-9861469] p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)
(inferredTo)	[BlackBoxEvent:R-HSA-9861484] Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow

Cite Us!