Reactome | DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)

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DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10324624
displayName	DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)
eventOf	[Pathway:R-CFA-9840373] Cellular response to mitochondrial stress - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9840415] DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) - Homo sapiens
input	[Complex:R-CFA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)
output	[Complex:R-CFA-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
precedingEvent	[Reaction:R-CFA-9840429] DELE1(143-515) binds EIF2AK1 (HRI) - Canis familiaris
regulatedBy	[PositiveRegulation:10324625] Positive regulation by 'DELE1(143-515):EIF2AK1 [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-9840415
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9840373] Cellular response to mitochondrial stress
(inferredTo)	[BlackBoxEvent:R-HSA-9840415] DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)

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